Safeguarding the cell nucleus Illustration of the nuclear pore. The nucleus is guarded by a highly secure door, the so-called (Image: Biozentrum, University of Basel) nuclear pore, that controls the transport of substances from the cytoplasm to the cell nucleus and back. A research group of Argovia professor Roderick Lim of the University of Basel has now shown that different shuttle proteins occupy the nu- clear pore to prevent unsolicited leakage of molecules. These proteins form an escape-proof, fail-safe mechanism by compen- sating for one another to fortify the pore. Media release: http://bit.ly/4142QYL 26 SNI Annual Report 2022