As part of the work, I synthesized and functionalized mesoporous silica nanoparticles (MSNs) and embed- ded them into the hydrogel matrix to create nano- composite systems. These nanoparticles were de- signed to enhance the hydrogel’s mechanical prop- erties. The application of various analytical tech- niques including dynamic light scattering (DLS), zeta potential measurements, transmission electron mi- croscopy (TEM), Fourier-transform infrared spectros- copy (FTIR), and nuclear magnetic resonance spec- troscopy (NMR) then ensured that I obtained exten- sive information about the materials used and was able to evaluate them. One of the most important aspects of the project was optimizing the hydrogel’s pH-responsive crosslink- ing mechanism, which allowed us to control gelation and achieve reliable self-healing behavior. I also tested the final systems for injectability, in vitro sta- bility, and mechanical performance. Rheological analysis provided especially interesting insights into the behavior of the hydrogel under stress, which I explored in detail in my thesis. Positive experience My work contributes to the broader field of bioma- terials by presenting a hydrogel platform that brings Further information: MERLN - Institute for Technology-In- spired Regenera- tive Medicine Nanoscience study program University of Basel Self-healing hydrogel Master`s thesis in Maastricht During my six-month research stay at the MERLN Institute in the Netherlands, I worked on my master’s thesis, focusing on the development of an injectable, self-healing hydrogel with potential applications in regenerative medicine. The aim was to design a hydrogel system based on 8-arm polyethylene glycol, intended for minimally invasive therapeutic delivery while supporting the body’s natural ability to repair bone tissue. For her master’s thesis, Selina Eng wanted to gain experience outside Basel. Maastricht is particularly easy to discover by bike. Guest article by Selina Eng 16 SNI INSight June 2025