“LeadXpro specializes in mem- brane protein structure-based drug discovery, integrating cryo-EM, conventional/serial/ time-resolved X-ray crystallog- raphy, and a strong biophysics platform to advance novel medicine for our research part- ners. Electron diffraction is an emerging complementary tech- nology, particularly valuable for nano-sized crystals and for the detailed analysis of hydrogen atoms, which are not possible with conventional X-ray crys- tallography and cryo-EM.” Dr. Robert Cheng, leadXpro AG “ELDICO Scientific develops dedicated electron diffractome- ters and advances electron dif- fraction methodology through its Basel Application Center. The company combines commercial instrument expertise with ongo- ing method development, en- abling structural determination across diverse crystalline mate- rials. Through this collaboration, ELDICO contributes its electron diffraction capabilities to expanding methodological reach into challenging protein targets.” Dr. Gunther Steinfeld, ELDICO Scientific AG The researchers performed the elect- ron diffraction measu- rements using the ED-1 electron diffrac- tometer, which was developed specifically for such investigations by project partner ELDICO Scientific. (Image: V. Panneels, Paul Scherrer Institute PSI) 49 SNI Annual Report 2025